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Formulation

The guiding principle behind the formulation design was to use only serum components at serum levels.


Design Principles

AQIX® RS-I, ( 'I' standing for Inotropic) the company’s lead product, is a patented, universal volume replacement for human serum and interstitial fluid.

The guiding principle behind the formulation design was to use only serum components at serum levels. A direct comparison of the patented formulation of AQIX® RS-I to that of serum and interstitial fluid is shown below.

Component
AQIX® RS-I
Human Serum mmol/L
Interstitial Fluid
Sodium ions 135 131-148 136
Potassium ions 5.0 3.4-5.2 4.4
Calcium ions 1.25 1.12-1.46 1.18
Magnesium Ions 0.45 0.38-0.72 0.51
Chloride Ions 119 101-111 117
Bicarbonate ions 25 21-29 23.9
Organic acid 5 (BES) 6.4 (Imidazole) 7.0
Glucose 10 3.6-6.1 3.3-3.6
Glycerol 0.11 0.131 0.087
Glutamate 300 20-110 cf. serum
Glutamine 400 140-570 cf. serum
Aspartate 20 µmols/L 1-11 µmols/L cf. serum
Carnitine 50 µmols/L 35-85 µmols/L cf. serum
Choline 10 µmols/L 18-70 µmols/L cf. serum
Thiamine Pyrophosphate 40 nmols/L 6-135 nmols/L cf. serum
Human insulin 28 mIU/L 6-35 mIU/L 24 mIU/L
pH @ 37°C 7.30-7.46 7.32-7.45 7.35-7.38
Osmolality (mOsm/kg) 265-286 264-290 264-282

The Benefits of AQIX® RS-I

  • Human and animal cells, tissues and organs can be kept viable both hypothermically and normothermically for significantly longer periods than previously achieved with conventional media.
  • Cell membrane receptors of all cell types are held in an optimal, sensitized state and react as they would in-vivo.
  • AQIX® RS-I can improve the predictability of preclinical potency and safety assays.

If you would like to trial a sample of AQIX® RS-I for research applications or require further information, please contact us using the contact section of the web site.